Mesenchymal stem cells

Rheumatic and musculoskeletal diseases (RMD) result in reduced mobility and have a high impact on health and quality of life. In 2020, 100 million Europeans will suffer from osteoarthritis (OA), degenerative disk disease (DDD), rheumatoid arthritis (RA). RMD have a high medico-economic impact related to chronicity and disability. Therefore, patients with early-onset disease must be identified to propose efficient therapies, and innovative treatments are needed. Development of regenerative and rehabilitation medicine for restoring mobility and function in tissues requires a coordinated effort between scientists, engineers and clinicians. Importantly, full rehabilitation may need for proper association of innovative regenerative stem cell biology, imaging as well as rehabilitation. 

Scientific objectives:

• to understand biologic events leading to cartilage formation, including cell interactions, chondral niche as well as epigenetic & metabolic associated with stem cell fate.
• to develop organoids and use embryologic models to decipher the mechanism involved in joint as functional organ development.
• to validate our strategy in in vivo models
• to translate in the clinic.