STEM CELLS, MACROPHAGESAND REGENERATIVE BIOLOGY

Farida Djouad

Leader

Contact information:
Phone : +33 4 67 33 04 75
e-mail : farida.djouad@inserm.fr
Twitter: @DjouadLab
The group members:

 

Farida DJOUAD (CRCN/Inserm)

Audrey BARTHELAIX (IE/Inserm)

Gautier TEJEDOR (IE/MedXCell)

Claudia TERRAZA (IE/INSERM)

LOPEZ Rafael CONTRERAS (Post-doc/UM)

Béryl LAPLACE-BUILHE (Post-doc/UM)

Dora SAPEDE (Post-doc/Inserm)

Sarah  BAHRAOUI (PhD-Student)​

Benoit BODIC (PhD-Student)​

Candice BOHAUD (PhD-Student)​

Damien LAOUTEOUET (PhD-Student)​

Keywords

Stem cell

Blastemal

Regeneration

Macrophage

Zebrafish

Mouse embryo   

 

The project of the group aims at identifying the cells that orchestrates regeneration in regenerative species by controlling the immune response as well as the proliferation, differentiation and fate of local stem cells. Our breakthrough approach based on our recent in vivo proof of concept study will allow us to provide a novel source of cells that will control inflammation and enhance tissue regeneration in degenerative and inflammatory diseases.

The discovery of Mesenchymal Stem Cells (MSC) immunoregulatory properties was pioneered by our group in the early 2000s. Since we have intensively investigated the underlying mechanisms and lately demonstrated, in an in vivoproof-of-concept study, that PPARβ/δ expression level predicts MSC immunomodulatory potential and that its repression enhances their therapeutic effects in murine arthritis. Considering the promising therapeutic effect of MSC both in preclinical and clinical studies as well as the pivotal role of PPARβ/δ on their immunoregulatory properties, the first axis of our project consists infurther investigatingthe role PPARβ/δ on MSC therapeutic properties.

The second axis aims at identifying the basis of epimorphic focusingon the role of the paracrine factors produced by neural crest derived cells (NCC) and macrophagesthat accumulate at the wound site and that participate to the regeneration process. To that end we are using two different vertebrate models of regeneration: zebrafish larva (Danio rerio) caudal fin and forelimb bud of the E10.5 mouse embryo.

Bibliographical references