Institute for Regenerative Medicine and Biotherapy
- IRMB -

Our mission is to change human health through a deep understanding of immune cells and stem cells biology..


IRMB - UMR1183

The Institute for Regenerative Medicine and Biotherapy (IRMB) associates the University Hospital of Montpellier (CHU Montpellier), the INSERM and the University of Montpellier (UM). IRMB gathers scientist and clinicians on regenerative medicine and innovative immunotherapies.
The aim of IRMB is to facilitate the transfer of research on stem cell biology to clinical applications in coordination with clinicial specialists in chronic diseases (rheumatoid arthritis, lung disease, liver disease, neurodegenerative disease, ageing, rare genetic diseases, autoinflammatory disorders,  diabetes, musculoskeletal disorders)

4 Research teams

Mesenchymal stem cells

Metabolism, regeneration biology and cell therapies applied to osteoarticular diseases

Pathophysiology and immunotherapy

Inflammatory disorders

Genome and Stem Cell Plasticity

in Aging

Lymphocyte differentiation, tolerance and metabolism: basis for biotherapies and engraftment

basis for biotherapy

service offering



Coordinator: Christian JORGENSEN

Cytometry facilities "MRI"

Manager : Christophe DUPERRAY


Supervision : Jean-Marc Lemaitre

Transcriptome / NGS core facilities

Manager: Véronique PANTESCO

Clinical Proteomics "PPC"

Supervision : Christophe HIRTZ

Bioinformatics and Biomarkers

Manager : Thérèse COMMES


Coordinator: Christian JORGENSEN


Manager : Moustapha Moussa ABBA


Manager : Anne-Laure BONNEFONT

Teachings "DU & Master"

Regenerative medicine "Cell and gene therapy"

From 15 to 19 November 2022

Room n°1 and 2 - IRMB -

  • Introduction on regenerative medicine. John De Vos
  • Pluripotency: embryonic stem cells, biology and ethical aspects. John De Vos
  • Stem cells from cord blood. Jean-Luc VEYRUNE 
  • Cell reprogramming (iPS) and therapeutic applications.          John De Vos
  • Hematopoietic stem cells: biology and clinical applications. Jérôme MOREAUX
  • Regulations, role of A.N.S.M. and quality management in cell therapy. Boris CALMELS
  • Sampling of peripheral and medullary hematopoietic cells for therapeutic use: organizational and technical aspects. Tarik KANOUNI
  • Natural killer (NK) cells in anti-tumor immunotherapy. Martin VILLALBA
  • Immunotherapy with Chimeric Antigen Receptors-modified T Cells (CARTs). Guillaume CARTRON
  • MTI: innovative therapy drugs; pharma regulations (BPF).  Adeline QUINTARD
  • Diversity of neuronal tissue: Neural stem cells, purification, culture, growth and differentiation factors, animal models, gene therapy. Jean-Philippe HUGNOT
  • Biology of bone and cartilage repair, mesenchymal stem cells, purification, culture, differentiation, animal models. Clinical applications. Yves-Marie PERS
  • Mesenchymal stem cells in clinical trials: historical and prospective. Christian JORGENSEN
  • Inter-cellular connections by nanotubes between mesenchymal stem cells and target cells. Marie-Luce VIGNAIS
  • Bioproduction of mesenchymal stem cells. Claire GONDEAU
  • Introduction to gene therapy and lentiviral vectors. Pierre CORBEAU
  • Adenoviral vectors. Franck MENNECHET
  • Muscle stem cell biology: Muscle tissue diversity, stem cells muscle, purification, culture, animal models, gene therapy. CARNAC Gilles
  • Regeneration: lessons from embryology. Candice BOHAUD

From 22 to 26 November 2022

Room n°1 and 2 - IRMB -

  • Introduction (2nd week). Said ASSOU
  • Neurodegenerative diseases, innovative therapeutic approaches: transplants, viral vectors. Eric THOUVENOT
  • Organoids: the third dimension. Said ASSOU
  • Stem cells from the inner ear: isolation, culture, differentiation and possible applications of cell therapy in the treatment of sensorineural hearing loss. Azel ZINE
  • Engineering of supporting tissues, biomaterials and controlled release of proteins / peptides. Marie MORILLE

  • Pancreatic stem cells. Islets of Langerhans. Stephane DALLE
  • Gene and cell therapy of inherited retinal dystrophies. Viki KALATSIS
  • Use of cardiomyocytes derived from iPS in the treatment of cardiac pathologies: modeling and cell therapy. MELI Albano
  • Interactive session with group work on ethics. John DE VOS and Said ASSOU

  • Tissue bank and corneal transplant. Guilhem COUDERC
  • Cryobiology: the art of freezing cells. Nicolas BUILLES
  • Substitute therapeutics in corneal pathologies, design and development in Tissue Bioengineering. Nicolas BUILLES
  • Contribution of multi-color cytometry for the study of stem cells. Guilhem REQUIRAND
  • Bioinks and biofabrication. Gilles SUBRA


Université Montpellier
CHU Montpellier
Muse Montpellier
European commission
Investissement d'avenir
Ecell France


Institute for Regenerative Medicine & Biotherapy (IRMB) Centre Hospitalier Régional Universitaire de Montpellier Hôpital Saint Eloi

80 rue Augustin Fliche
34295 MONTPELLIER – Cedex 5

Phone : +33 (0)4 67 33 01 90
Fax : +33 (0)4 67 33 01 13