The EVe Facility is a state-of-the-art academic research platform dedicated to supporting research groups, hospitals, and companies working in the field of extracellular vesicles (EVs). We offer cutting-edge technologies, expert know-how in sample preparation, and a full range of services for EV production, isolation, and characterization.
EV Isolation Services:
We provide access to multiple EV isolation techniques, tailored to your research needs:
EV Characterization Services:
Our facility offers comprehensive EV characterization using advanced technologies:
We also provide complementary standard characterization methods such as:
EV functional assay services:
Our facility offers various functional assays for testing EV functions (on demand).
Consultation Services:
Our experts are available to guide you in designing workflows for EV separation, characterization, and downstream analysis.
What we offer:
Pricing informations:
For pricing or a personalized quote, please contact us directly (marie.maumus[a]inserm.fr or daniele.noel[a]inserm.fr). We’re happy to assist you in planning your project.
Partner with the EVe Core Facility to accelerate your EV research with precision, innovation, and reliability.
Danièle Noël
daniele.noel[a]inserm.fr
Marie Maumus
marie.maumus[a]inserm.fr
Original publications:
− Anti-aging effect of extracellular vesicles from mesenchymal stromal cells on senescence-induced chondrocytes in osteoarthritis. Boulestreau J, et al. Aging (Albany NY). 2024 Nov 22;16(21):13252-13270
− Extracellular vesicles from senescent mesenchymal stromal cells are defective and cannot prevent osteoarthritis. Boulestreau J, et al. J Nanobiotechnology. 2024 May 16;22(1):255.
− Lung Fibrosis Is Improved by Extracellular Vesicles from IFNγ-Primed Mesenchymal Stromal Cells in Murine Systemic Sclerosis. Rozier P, et al. Cells. 2021 Oct 13;10(10):2727.
− Extracellular Vesicles Are More Potent Than Adipose Mesenchymal Stromal Cells to Exert an Anti-Fibrotic Effect in an In Vitro Model of Systemic Sclerosis. Rozier P, et al. Int J Mol Sci. 2021 Jun 25;22(13):6837.
− Mesenchymal stromal cells-derived extracellular vesicles alleviate systemic sclerosis via miR-29a-3p. Rozier P, et al. J Autoimmun. 2021 Jul;121:102660.
− TGFBI secreted by mesenchymal stromal cells ameliorates osteoarthritis and is detected in extracellular vesicles. Ruiz M, et al. Biomaterials. 2020 Jan;226:119544.
− Mesenchymal stem cells-derived exosomes are more immunosuppressive than microparticles in inflammatory arthritis. Cosenza S, et al. Theranostics. 2018 Feb 3;8(5):1399-1410.
− Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis. Cosenza S, et al. Sci Rep. 2017 Nov 24;7(1):16214.
Reviews:
− Therapeutic potential of extracellular vesicles derived from mesenchymal stromal cells in rheumatic diseases. Bertolino GM, et al. Nat Rev Rheumatol. 2024 Jun;20(6):389.
− Recent Advances in Extracellular Vesicle-Based Therapies Using Induced Pluripotent Stem Cell-Derived Mesenchymal Stromal Cells. Bertolino GM, et al. Biomedicines. 2022 Sep 14;10(9):2281.
− Development of extracellular vesicle-based medicinal products: A position paper of the group “Extracellular Vesicle translatiOn to clinicaL perspectiVEs – EVOLVE France”. Silva AKA, et al. Adv Drug Deliv Rev. 2021 Dec;179:114001.
− Extracellular vesicles from mesenchymal stromal cells: Therapeutic perspectives for targeting senescence in osteoarthritis. Boulestreau J, et al. Adv Drug Deliv Rev. 2021 Aug;175:113836.
− Mesenchymal Stromal Cell-Derived Extracellular Vesicles Regulate the Mitochondrial Metabolism via Transfer of miRNAs. Loussouarn C, et al. Front Immunol. 2021 Mar 16;12:623973.
− Mesenchymal Stem Cell-Derived Extracellular Vesicles: Opportunities and Challenges for Clinical Translation. Maumus M, et al. Front Bioeng Biotechnol. 2020 Sep 10;8:997.
− Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging. Boulestreau J, et al. Front Cell Dev Biol. 2020 Feb 21;8:107.
− Pathogenic or Therapeutic Extracellular Vesicles in Rheumatic Diseases: Role of Mesenchymal Stem Cell-Derived Vesicles. Cosenza S, et al. Int J Mol Sci. 2017 Apr 22;18(4):889.
− Mesenchymal stem cells in regenerative medicine applied to rheumatic diseases: role of secretome and exosomes. Maumus M, et al. Biochimie. 2013 Dec;95(12):2229-34.